Simulate eQTL reference panel

The function creates a eQTL reference panel for MOSTWAS methods with genotypes, expression, mediator intensities, and QTLs.

simGWAS(geno.loc, geno.dis, ngwas, b_qtls.loc, b_qtls.dis, var_explained)

Arguments

geno.loc	data.frame, reference genotypes for local SNPs
geno.dis	data.frame, reference genotypes for distal SNPs
ngwas	integer, sample size
b_qtls.loc	vector, local eQTLs effect sizes
b_qtls.dis	vector, distal eQTLs effect sizes
var_explained	numeric, total variance explained in phenotype

Value

list of GWAS summary statistics, total eQTL effect size, matrix of simulated genotypes, vector of trait