Perform permutation test for the total mediation effect

The function takes in a SNP-mediator set-gene triplet and computes the total absolute mediation effect and permutation test P-value

permuteTME(
  snp,
  expression,
  mediators,
  covs,
  nperms = 1000,
  parallel = "no",
  nc
)

Arguments

snp	vector, SNP of interest
expression	vector, gene expression of interest
mediators	data frame, mediators of interest
covs	data frame, covariates
nperms	integer, number of permutations for the null distribution
parallel	character, boot parallel input
nc	integer, number of cores

Value

estimate of TME and the permutation P-value