Use mutual linearity to find cell-type gene signatures and do deconvolution

The function finds cell-type gene signatures and does deconvolution using the linseed pacakge

linCor(
  yref,
  iters = 100,
  pval = 0.01,
  n.types = NULL,
  scree = "cumvar",
  logTransform = F
)

Arguments

yref

matrix, numeric expression matrix
iters

numeric, number of interations
pval

numeric, p-value cutoff
n.types

integer, number of cell-types
scree

character, method to estimate n.types if n.types is NULL
logTransform

logical, T/F if yref is in log-scale

Value

list with cell-type proportions and expression